Clofibrate Reversal of Platelet Hypersensitivity in Hyperbetalipoproteinemia

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Clofibrate reversal of platelet hypersensitivity in hyperbetalipoproteinemia.

Platelet function was evaluated in 29 patients with familial hyperbetalipoproteinemia; 17 were untreated and 12 were receiving clofibrate (Atromid-S). In comparison with 26 normal subjects, the untreated patients aggregated in response to 1/3 the concentration of adenosine diphosphate (ADP), '/25 the concentration of epinephrine, and '/4 the concentration of collagen. Treatment with clofibrate,...

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ژورنال

عنوان ژورنال: Circulation

سال: 1974

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.50.3.570